Is a new variant behind the coronavirus disaster in India?


The mind-boggling speed with which the coronavirus overwhelmed Indian health systems has triggered a global alarm over the viral variant that has emerged in the subcontinent.

the Variant B. 1.617 has been blamed by some for the surge in infections in India, which has recorded more than 350,000 confirmed cases Monday alone, a world record for a county in one day. Health experts believed the true figure was likely much higher.

But scientists have urged not to jump to rush conclusions about how much the variant alone is responsible for the skyrocketing increase in cases in recent weeks, which has caused 2,800 confirmed deaths in India as of Monday alone. They said there was little hard evidence for the virulence and transmissibility of the Indian variant and point to other possible factors.

“Despite the alarming spike in new cases with India’s second wave, there is simply not enough evidence to blame the variants,” said Nancy Jaser, infectious disease analyst at GlobalData, a analysis company that follows mutations.

When did the “Indian variant” evolve and to what extent is it widespread?

The B. 1.617 variant was first registered in a global viral genome database in early October, just two weeks after the Variant B.1.1.7 was originally detected in the UK. B. 1.617 has circulated in India since and has spread internationally. About 20 countries have reported cases, mostly in travelers from India.

The problem is that, relative to the size of its population, India has achieved very little genome sequencing this is the only reliable way to follow the evolution of variants. The extent of the involvement of variant B. 1.617 in the outbreak in India is therefore unknown, although it represents about two-thirds of the genomes reported by the country to the global GISAID database.

Jeffrey Barrett, director of the Covid-19 Genomics Initiative at the Wellcome Sanger Institute in Cambridge, pointed out that a number of variants were present in India, including one from Britain.

B.1.1.7, which scientists have concluded is more transmissible, was the dominant variant of the Covid-19 wave in the UK at the end of 2020, and then spread to mainland Europe.

“There is evidence of multiple overlapping epidemics in India, rather than a monolithic epidemic,” Barrett said. “Which makes sense because it is a huge and heterogeneous country.”

The health worker transports the patients. There is evidence of multiple overlapping epidemics © Ajit Solanki / AP

B. 1.617 is it particularly virulent or transmissible?

The original variant of B. 1.617 contains 13 genetic mutations which lead to changes in the virus. These include two in the spike protein which has been linked in other variants (such as those identified in South Africa and Brazil) to increased transmissibility and the ability to escape immunity conferred by vaccination or previous infection. But there is not enough evidence from epidemiological studies or laboratory experiments to confirm that this is also the case for B. 1.617.

“You have to watch these things without panicking,” Barrett said. “The fact that [the variant that originated in India] has not spread yet [widely] in the UK, even though it has been on the british coast since February, suggests that it is unlikely to be as transmissible as B.1.1.7. “

Adding to the uncertainty, B. 1.617 is itself “evolving and diverging over time,” according to Sharon Peacock, director of the Covid-19 UK Genomics Consortium. Scientists have already detected three descendants – called B. 1.617.1, B. 1.617.2 and B. 1.617.3 – with slightly different mutations. The practical implications of these strains are unknown.

References in the media and online to “double mutations” in Variant B. 1.617 were “inaccurate, have no special meaning and should be avoided,” Peacock added.

Prime Minister Narendra Modi addressed a rally last month ahead of a march to celebrate India’s 75th independence anniversary © Reuters

Will the vaccines be less effective against B. 1.617 than against other variants?

Again, it is not clear. Vaccines developed to fight the original coronavirus that appeared in Wuhan in 2019 also appear to work against the B.1.1.7 variant that emerged in the UK, although they appear to be. less efficient against variants originating from South Africa and Brazil.

“It is not yet known whether they will maintain their effectiveness against the new variants appearing in India, but they do. . . likely they will at least have some effectiveness, ”said Peter English, a retired UK-based communicable disease consultant.

Since only about 10% of the Indian population has been vaccinated, “variants are not yet under great pressure from vaccine immunity, so there is no great pressure for mutants of vaccine escapes appear, ”he added.

Sadhus, Hindu holy men, take a dip in the Ganges during Kumbh Mela, one of the world’s largest religious festivals where millions of people gathered even as Covid cases rose © Danish Siddiqui / Reuters

If the new variant is not the main cause of the Covid-19 crisis in India, what could be responsible?

The evolution of the coronavirus crisis in India was also driven by other factors including its low vaccination rate and limited hospital capacity, as well as decisions made by leaders such as Prime Minister Narendra Modiand the tolerance of large political and religious gatherings.

“The focus has been on variant B. 1.617,” said Michael Head, senior researcher in global health at the University of Southampton in the UK. “But it is the mix of susceptible populations that ultimately leads to the transmission of infectious respiratory diseases.”

He referred to mass rallies in India in March and April associated with political campaigns, international cricket matches between India and England “with full stadiums and few masks”, and several large Religious holidays, like the Kumbh Mela, an event in which millions of people participated.

The Hajj pilgrimage in Saudi Arabia and the traditional New Year celebrations in China have been much smaller than the Kumbh Mela, Head said.

“India may have reduced its celebrations a bit, but millions of people have gathered for Kumbh Mela at different sites, and thousands of new cases of coronavirus are already confirmed in revelers,” he said. declared.



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